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General
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Answer multiple choice questions 1-30 and transfer answers to scantron to turn in. Print pages 1 and 2, answer questions and bring to class.
Cystic fibrosis: tying it all together questions and preparation for the Final Exam.
Match these terms with the blanks below: chloride ion, osmosis, mutation, osmosis
Cystic fibrosis is a disease that results from a ______________ in the
gene for the
___________ pump. Normal pumps function to transport chloride
ions into the mucus outside the cells lining the air passage ways.
This keeps the mucus more salty than the cell, causing __________ to
occur.
This draws water out of the cell due to a difference in solute concentration.
Circle the correct term in italics.
The mucus is kept hypertonic, hypotonic or isotonic, to
the cell contents.
The pump is a membrane protein functioning in facilitated diffusion,
active transport, signal transduction.
To track the inheritance of this disease:
C is used to denote a normal pump
c is used to demote a defective pump
Using C's and c's, write the genotype of
the following individuals in the blanks.
a. Homozygous dominant __ __
b. Heterozygous
__ __
c. Homozygous recessive __ __
Which above has the disease phenotype? ___
Which one is called a disease carrier? ___
Which two are phenotypically normal? ______
Which of the above labeled molecules a-e most likely contains the mutated
gene for cystic fibrosis? ___
Which is most likely for defective pump being formed? ___
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These questions have been selected from the test bank provided by the
text
book publisher.
1. A couple who are both carriers for the gene for cystic fibrosis
have
two children who have cystic fibrosis. What
is the probability that
their next child will have cystic fibrosis?
a. 0%
b. 25%
c. 50%
d. 75%
e. 100%
2. A couple who are both carriers for the gene for cystic fibrosis
have
two children who have cystic fibrosis. What
is the probability that
their next child will be phenotypically normal?
a. 0%
b. 25%
c. 50%
d. 75%
e. 100%
3. What do you call a genetic cross between an individual of
unknown
genotype and a homozygous recessive?
a. a self-cross
b. a testcross
c. a hybrid cross
d. an F 1 cross
e. a dihybrid cross
4. In crossing a homozygous recessive with a heterozygote, what
is the
chance of getting a homozygous recessive phenotype
in the F 1
generation?
a. zero
b. 25%
c. 50%
d. 75%
e. 100%
5. In snapdragons, heterozygotes have pink flowers, whereas the
two
homozygotes have red flowers or white flowers.
When plants with red
flowers are crossed with plants with white
flowers, what proportion
of the offspring will have pink flowers?
a. zero
b. 25%
c. 50%
d. 75%
e. 100%
6. What was the most significant conclusion that
Gregor Mendel drew
from his research?
a. There is considerable genetic variation
in garden peas.
b. Traits are inherited in discrete units,
one from each parent.
c. Dominant genes occur more frequently than
recessive ones.
d. Genes are composed of DNA.
e. An organism that is homozygous for many
recessive traits is at a
disadvantage.
7. A couple has three children, all of whom have brown eyes and
blond
hair. Both parents are homozygous for brown
eyes (BB), but one is a
blond (rr) and the other is a redhead (Rr).
What is the probability
that the next child will be a brown-eyed redhead?
a. 1/16
b. 1/8
c. 1/4
d. 1/2
e. 1
Use the information below to answer the following question(s).
A woman and her husband both show the normal phenotype for
pigmentation, but both had one parent who was an albino. Albinism
is
an autosomal recessive trait.
8. What is the probability that their first child will be an albino?
a. 0%
b. 25%
c. 50%
d. 75%
e. 100%
9. If their first two children have normal pigmentation, what
is the
chance that their third child will be an albino?
a. 0%
b. 25%
c. 50%
d. 75%
e. 100%
10. What is the chance that their fourth child will have a homozygous
genotype?
a. 0%
b. 25%
c. 50%
d. 75%
e. 100%
11. The advantage of chorionic villi sampling over amniocentesis
is that
CVS
a. detects chromosomal abnormalities not detected
by amniocentesis.
b. can give results much earlier in the pregnancy
than
amniocentesis.
c. is less likely to cause miscarriage than
amniocentesis.
d. can detect chemical abnormalities not detected
by amniocentesis.
e. results are more reliable than amniocentesis
results.
------------------------------
Use the information given below to answer the following question(s).
A woman who belongs to blood group A and is Rh positive has a
daughter who is O positive and a son who is B negative. Rh positive
is a simple dominant over Rh negative.
12. Which of the following is a possible genotype for the son?
a. BB Rh- Rh-
b. OB Rh+ Rh-
c. OB Rh- Rh-
d. OO Rh- Rh-
e. AB Rh- Rh-
13. Which of the following is a possible genotype for the woman
(mother)?
a. AA Rh+ Rh-
b. AB Rh+ Rh+
c. OO Rh+ Rh-
d. AA Rh+ Rh-
e. AO Rh+ Rh-
14. Which of the following is a possible phenotype for the father?
a. A negative
b. O negative
c. B negative
d. B positive
e. O positive
15. Fill in the most likely genotypes in the following pedigree.
16. A sexually reproducing animal has two unlinked genes (not
on same chromosome), one for head
shape and one for tail length. Its genotype
is HhTt, (i.e. heterozygous for both traits). Which of the
following genotypes is most likely in a gamete
from this organism?
a. HT, Ht
b. Hh, tt
c. HhTt
d. T
e. tt
Use the following information to answer the question(s).
Albinism (lack of skin pigmentation) is caused by a recessive
autosomal allele. A man and woman, both normally pigmented, have
an
albino child together.
17. For this trait, what is the genotype of the albino child?
a. homozygous dominant
b. homozygous recessive
c. heterozygous
d. hemizygous
e. unknown, because not enough information
is provided
18. Another couple who is also heterozygous for albinism,
decides to have children.
What is the probability that they will have two albino children
in a row?
a. zero
b. 1/4
c. 1/2
d. 1/8
e. 1/16
19. How many genetically different gametes could be produced through
independent
assortment by an individual with the genotype
Aa Bb CC Dd EE? Remember,
gametes should contain no pairs of homologous
chromosomes. Assume these
different genes are not linked, i.e. not on
the same chromosome.
a. 4
b. 8
c. 16
d. 32
e. 1/64
20. The probability that four coins will come up heads when flipped
simultaneously is
a. 1/4 (0.25).
b. 1/2 (0.5).
c. 1/8 (0.125).
d. 1/16 (0.062).
e. 1/64 (0.016).
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Use the choices shown below to answer the following question(s).
Each choice may be used once, more than once, or not at all.
a. Huntington's disease
b. Tay-Sachs disease
c. phenylketonuria
d. hemophilia
e. sickle-cell anemia
21. Effects of this recessive single gene can be completely overcome
by
regulating the diet of the affected individual.
22. This is caused by a dominant single gene defect and generally
does
not appear until the individual is 30-40 years
of age.
23. Individuals with this disorder are unable to metabolize
gangliosides, which affects proper brain development.
Affected
individuals die in early infancy.
24. Substitution of the "wrong" amino acid in the hemoglobin protein
results in this disorder.
------------------------------
25. When the ribosome reads the defective code and inserts the
wrong
amino aicd in the forming hemoglobin
molecule, it is directly effecting
which structure of the protein?
Pick the most proximate structure.
a. primary
b. secondary
c. tertiary
d. quarternary
------------------------------
Refer to the pedigree chart in Figure 13.1 for a family, some
of
whose members exhibit the trait for woolly hair. Affected
individuals are indicated by an open square or circle.
26. What is the genotype of individual B-5?
a. WW only
b. Ww only
c. ww only
d. WW or ww
e. ww or Ww
27. What is the genotype of individual D-3?
a. WW only
b. Ww only
c. ww only
d. WW or ww
e. ww or Ww
28. Recipes are instructions on how to prepare food, just like
genes are
instructions the cell uses to make proteins.
Using this analogy, a
cookbook is analogous to
a. a nucleus.
b. a chromosome.
c. a pair of homologous chromosomes.
d. a gamete.
e. a zygote.
29. Assume a cassett tape contains 5,423 different songs, and
complete the following
analogy: A cassett tape is to a song
as a chromosome is to a ________.
a. gene
b. DNA molecule
c. nucleotide
d. base pair
e. RNA molecule
30. Blueprints contain specific instructions for constructing
a
building. The room you are sitting in now
was constructed by using
the instructions on a set of blueprints. The
relationship between
blueprint and building is analogous to the
relationship between
a. chromosomes and genes.
b. genes and alleles.
c. dominant and recessive alleles.
d. segregation and independent assortment.
e. genes and proteins
General
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