Sci. American, Sept 2004, page 108, Einstein and Newton Genius Compared, Alan Lightman.

Abstracted ideas about vitalism and determinism.

Prior to Issac Newton most thinkers assumed that gods controlled events and how the
world worked was beyond the understanding of "mere mortals."

Sir Issac Newton ..."conquered the notion that some areas of knowledge were inaccessible to the human mind, an idea ingrained in Western culture for centuries.  Newton, with his monumental work "The Principia" (1687) swept all this aside.
It now appeared that all things in the physical world were comprehensible, mechanistic, predictable, deterministic.

Albert Einstein brought about another transition with his special relativity theory (1905).
Physical things could no longer be revealed by observation of the external world.
    space-time
    relativity
Einstein showed that scientists must begin within their own minds, and use mathematics to pursue hypotheses.
Einstein overturned centuries of thought about the supremacy of observation, empirical study and experience.
Probability replaced Newton's predictability.
The universe could not be understood intuitively but only mathematically.  (Plato's Cave)
 
 
 
Isaac Newton was the greatest English mathematician of his generation. He laid the foundation for differential and integral calculus. His work on optics and gravitation make him one of the greatest scientists the world has known.  1643 - 1727

 
 
Albert Einstein contributed more than any other scientist to the modern vision of physical reality. His special and general theories of relativity are still regarded as the most satisfactory model of the large-scale universe that we have. 1879 - 1955